Looks like fellow Cervelo enthusiast "sacredsurfer" got them to work on his S1, see: http://forums.cervelo.com/forums/t/72.aspx?PageIndex=190
I emailed him and am waiting to see how he did it and I am curious what width tires he is using and how much clearance at his fork crown and rear brake bridge. In my case, clearance under my 3T fork crown on my R3 is about 1.5 mm or so with my 25c Michelin Axial Pros and about. I went ahead and order a set of Crud RoadRacers from Ribble to try them, knowing that they will not work, but with the intent of figuring out how to modify them so they will work.
EM3