Well, we are talking best riging race frames here anyway....S1 is VERY stiff. I'm pretty sure that 99% other-than Cervelo carbon frames are flexyer. Specially rear triange of S1 is hallmark of how alloy frames should be done.
Main differences in S1 vs. S2 is weight, price and comfort. You can quess what is where....
If I would be low budger racer, S1 would be my pick. Just add SRAM Rival qroup and few sets of Ksyrium Elites/SLR seats, 3T Pro parts, Michelin tyres...
Wheels and seats are first needet to change after race crashes so few extra sets for this and no carbon frame. I bet S1 can take some beating that any carbon frame can't. Low weight seat, may be S2/S3 seatpost to shave weight from top, low inertia/good price/good hub whees, solig/light bar/stem, light/sure working group...I really would like to see Cervelo going more SRAM!
On size 51-56 you get really nice looking bike. Pictures doesn't make it enoeght.